Best Argireline Creams – 2017 Reviews and Top Picks

It’s a common misconception that to achieve youthful skin, you need to either pay for expensive products or undergo invasive procedures. If you’re like most people who dread needles and overspending, these ideas can spell bad news.

Fortunately, cosmetic companies have found a means to incorporate a painless way of smoothing fine lines and wrinkles into their products. The answer is Argireline.

Although the trend can sound foreign to you, there are actually a lot of products that already contain Argireline on the market today. In case you’re thinking of adding this potent anti-aging component in your skincare regimen, then here are the 3 best Argireline creams you can start with.

What is Argireline?

Argireline has the same property as Botox. However, unlike Botox which is injected, Argireline is applied topically on the skin.

It is a derivative of Acetyl hexapeptide-3, a neuropeptide that blocks the communication between your facial nerves and muscles. It addresses wrinkles and fine lines by limiting the contractions on your face.

Because it’s a muscle relaxant, skin damage brought by excessive sun exposure might not respond well to this ingredient. People with thick skin may also not see results as visible as those with thinner skin.

One good reason to this is its mode of application. Because it is topical, it can only reach the superficial layers of the skin.

In terms of its general effectivity, a study released by the International Journal of Cosmetic Science showed that women who used Argireline cream for 30 days experienced a reduction of 30% on the depth of their wrinkles.

To reap the benefits of topical Argireline, it’s recommended that serums and creams should be applied twice a day.

Argireline vs. Botox

Although their function is a bit similar, Argireline is an entirely different substance from Botox. Some of their notable differences include:

  • Argireline is applied on the skin while Botox needs to be injected.
  • Because Botox is injected, it has a deeper effect. Argireline can only reach superficial layers of the skin.
  • Botox is more expensive.
  • Argireline is weaker than Botox.
  • Argireline alsohas a hydrating effect on the skin.

What makes a good Argireline cream?

Creams that contain Argireline are considered good in terms of managing the signs of skin aging. However, to make sure you get the best among these creams, here are some criteria you can use:

  • The highest concentration of Argireline in products is 20%. Choose creams with 10% or higher Argireline content.
  • It should be easily absorbed.
  • It must be convenient to apply.
  • It should be combined with an effective antioxidant.

Reviews of the Best Argireline Creams

Because of how in demand skin aging products are, it’s not surprising to find tons of cosmetic companies willing to add Argireline and its benefits to their list of ingredients. In case you find the choices confusing, we did the in-depth research to come up with the 3 best Argireline creams for you.

First Botany Cosmeceuticals Intensive Wrinkle Free Anti-Aging Eye Cream with Argireline

This product boasts 5% Argireline. It also has 5% of Leuphasyl, a pentapeptide that addresses wrinkles as well.

Aside from these ingredients, First Botany’s Anti-Aging Eye Cream includes Borage Oil, too. This substance is highly effective in restoring the intracellular moisture of the skin, particularly those that are chronically exposed to environmental factors.

The product is light on the skin and easy to apply. It helps boost collagen formation to nourish and tone the skin.

It has a creamy texture but not sticky in consistency. It also doesn’t have a strong scent.

Most reviewers expressed concern with how small the product’s bottle was. However, because it is an eye cream, you’ll only need a very little amount to cover the entire area.

Things We Liked

  • Not sticky
  • Doesn’t have a strong scent
  • Visible results in the first few applications

Things We Didn't Like

  • Small in size
  • Expensive compared to the quantity

Face Whisperer Day Cream with Argireline

Face Whisperer Day Cream has a higher concentration of Argireline at 10%. It also contains natural ingredients, such as Aloe, ginseng, and cucumber, to add nourishment to the skin.

The product has no parabens and fragrance. Once applied to the skin, you’ll feel a cooling effect.

Its texture is thick and creamy but it gets absorbed quickly into the skin. Although it's an effective moisturizer, it won’t make you feel oily and greasy.

While most users were able to see visible results right away, there are some people who experienced breaking out from using the cream.

People who bought and used the product enjoyed it’s jar packaging. It’s securely packaged and doesn’t look cheap.​

Things We Liked

  • No smell
  • Paraben-free
  • Argireline is at 10% concentration

Things We Didn't Like

  • May cause breakout to some people
  • Can be too thick to use as a day cream

Paloma Skin Therapy Perfect Peptide Skin Firming Cream

This product has 8% Argireline concentration by volume. Aside from this ingredient, it also has glycerin and coconut oil extract.

We particularly like the packaging of this cream as it comes in an airless pump. It doesn’t only make dispensing easier, but also decreases the chances of contamination.

In case you experience difficulty using the pump for the first time, we suggest tapping its bottom first. This frequently happens when the pumps get tossed and turned during shipment.

The cream is paraben and alcohol-free. It also has no fragrance, which users really like.

Another thing they like about the product is how it can moisturize without making the skin feel greasy and sticky. There’s also a bit of a stingy feeling after application which users relate to the product’s tightening effect.

Things We Liked

  • Good airless pump packaging
  • Less risk of contamination
  • Contains 8% Argireline

Things We Didn't Like

  • Not potent enough for some people


Argireline is a convenient choice when it comes to addressing wrinkles because it’s more affordable than Botox and comes with virtually no pain. Adding it to your beauty arsenal can decrease the puffiness, redness and fine lines around your face and neck.

Among these 3 Argireline creams, we find Face Whisperer Day Cream as our top choice.

We like that it has a high percentage of Argireline and a good combination of natural ingredients. This formulation enables the product to quickly deliver results to its users.​

Despite its thick consistency, this cream doesn't make the skin feel greasy. Instead, it provides a cooling effect after application.

Have you heard about Argireline? What other skin products with this ingredient do you use?​

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